1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione
CAS: 78269-85-9
Molecular Formula: C10H17NO5Si
1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione - Names and Identifiers
1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione - Physico-chemical Properties
| Molecular Formula | C10H17NO5Si |
| Molar Mass | 259.33 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Melting Point | 83-88°C(lit.) |
| Boling Point | 308.6±44.0 °C(Predicted) |
| Flash Point | 140.4°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.000675mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| Storage Condition | 2-8°C |
| Sensitive | 7: reacts slowly with moisture/water |
| Refractive Index | 1.479 |
1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione - Introduction
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione is an organic compound with the chemical formula C12H21NO5Si. It is a silicone derivative containing one trimethylsilyl group and one ethoxycarbonyloxy group. The properties of this compound are as follows:
Nature:
-Appearance: Colorless or yellowish crystal or powder
-Melting point: about 58-60°C
-Solubility: Soluble in some organic solvents, such as ether, acetone and methanol
Use:
-Chemical synthesis: 1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione can be used as a protecting group (protecting group) or an intermediate (intermediate) in organic synthesis. It can protect amino functional groups, prevent accidental chemical reactions in the reaction or selectively modify specific groups.
-Pharmaceutical field: This compound also has certain applications in drug development, for example, in the process of synthesizing specific drug molecules, it can be used as a protective dose or fixed reaction condition.
Preparation Method:
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2, the preparation method of 5-dione can be realized by the following steps:
1. the succinic anhydride (succinic anhydride) and trimethylethoxysilanol (trimethylsilylethanol) are reacted to generate trimethylethoxysilyl succinate (trimethylsilyl ethoxy succinate);
2. under alkaline conditions, heating trimethylethoxysilyl succinate and 3-amino sodium propionate (sodium 3-aminopanoate) reaction, generate 1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione.
Safety Information:
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2, there is no detailed scientific research and evaluation of the relevant safety information of 5-dione. However, as an organic compound, it should be used in accordance with laboratory safety procedures, including frequent hand washing, avoiding inhalation of aerosols or contact with skin, and wearing personal protective equipment. When handling and disposing of waste, relevant environmental protection regulations need to be followed. If you have any questions or need more safety information, please consult a chemical professional.
Nature:
-Appearance: Colorless or yellowish crystal or powder
-Melting point: about 58-60°C
-Solubility: Soluble in some organic solvents, such as ether, acetone and methanol
Use:
-Chemical synthesis: 1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione can be used as a protecting group (protecting group) or an intermediate (intermediate) in organic synthesis. It can protect amino functional groups, prevent accidental chemical reactions in the reaction or selectively modify specific groups.
-Pharmaceutical field: This compound also has certain applications in drug development, for example, in the process of synthesizing specific drug molecules, it can be used as a protective dose or fixed reaction condition.
Preparation Method:
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2, the preparation method of 5-dione can be realized by the following steps:
1. the succinic anhydride (succinic anhydride) and trimethylethoxysilanol (trimethylsilylethanol) are reacted to generate trimethylethoxysilyl succinate (trimethylsilyl ethoxy succinate);
2. under alkaline conditions, heating trimethylethoxysilyl succinate and 3-amino sodium propionate (sodium 3-aminopanoate) reaction, generate 1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione.
Safety Information:
1-({[2-(trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2, there is no detailed scientific research and evaluation of the relevant safety information of 5-dione. However, as an organic compound, it should be used in accordance with laboratory safety procedures, including frequent hand washing, avoiding inhalation of aerosols or contact with skin, and wearing personal protective equipment. When handling and disposing of waste, relevant environmental protection regulations need to be followed. If you have any questions or need more safety information, please consult a chemical professional.
Last Update：2024-04-09 19:05:52
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Product Name: N-[2-(trimethylsilyl)ethoxycarbonyloxy]succinimide Request for quotationCAS: 78269-85-9
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
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